DCCII-Based Novel Lossless Grounded Inductance Simulators With No Element Matching Constrains

In 1996, the differential current conveyor (DCCII) was introduced as a versatile active element with current differencing capability. Therefore, in this study, the usefulness of the DCCII is shown on six novel lossless grounded inductance simulator circuits. Proposed circuits simultaneously employ minimum number of elements, i.e. single DCCII, one capacitor, and two resistors. No passive element matching restriction is needed and all solutions are electronically tunable in case that one of resistors is replaced by MOSFET-based voltage-controlled resistor. The internal structure of the active element has been implemented using the TSMC 0.25 um SCN025 CMOS process BSIM3v3.1 parameters. Firstly, the performance of the selected inductor simulator is evaluated and subsequently verified in the design of 5th-order high-pass ladder and 2nd-order frequency filters. In addition, experimental results using commercially available AD844/ADs are given to verify the theoretical analysis and SPICE simulations

Realization of Resistorless Lossless Positive and Negative Grounded Inductor Simulators Using Single ZC-CCCITA

This paper is in continuation with the very recent work of Prasad et al. [14], wherein new realizations of grounded and floating positive inductor simulator using current differencing transconductance amplifier (CDTA) are reported. The focus of the paper is to provide alternate realizations of lossless, both positive and negative inductor simulators (PIS and NIS) in grounded form using z-copy current-controlled current inverting transconductance amplifier (ZC-CCCITA), which can be considered as a derivative of CDTA, wherein the current differencing unit (CDU) is reduced to a current-controlled current inverting unit. We demonstrate that only a single ZC-CCCITA and one grounded capacitor are sufficient to realize grounded lossless PIS or NIS. The proposed circuits are resistorless whose parameters can be controlled through the bias currents. The workability of the proposed PIS is validated by SPICE simulations on three RLC prototypes

Lossy/Lossless Floating/Grounded Inductance Simulation Using One DDCC

In this work, we present new topologies for realizing one lossless grounded inductor and two floating, one lossless and one lossy, inductors employing a single differential difference current conveyor (DDCC) and a minimum number of passive components, two resistors, and one grounded capacitor. The floating inductors are based on ordinary dual-output differential difference current conveyor (DO-DDCC) while the grounded lossless inductor is based one a modified dual-output differential difference current conveyor (MDO-DDCC). The proposed lossless floating inductor is obtained from the lossy one by employing a negative impedance converter (NIC). The non-ideality effects of the active element on the simulated inductors are investigated. To demonstrate the performance of the proposed grounded inductance simulator as an example, it is used to construct a parallel resonant circuit. SPICE simulation results are given to confirm the theoretical analysis

Current and Voltage Conveyors in Current- and Voltage-Mode Precision Full-Wave Rectifiers

In this paper new versatile precision full-wave rectifiers using current and/or voltage conveyors as active elements and two diodes are presented. The performance of these circuit solutions is analysed and compared to the opamp based precision rectifier. To analyze the behavior of the functional blocks, the frequency dependent RMS error and DC transient value are evaluated for different values of input voltage amplitudes. Furthermore, experimental results are given that show the feasibilities of the conveyor based rectifiers superior to the corresponding operational amplifier based topology

Current-Mode Dual-Phase Precision Full-Wave Rectifier Using Current-Mode Two-Cell Winner-Takes-All (WTA) Circuit

In addition to the recently proposed full-wave rectifier by Prommee et al. using voltage-mode (VM)two-cell winner-takes-all (WTA) circuit, we present current-mode (CM) precision full-wave rectifier using CM two-cell WTA circuit. The popular Lazzaro’s CM WTA circuit has been employed for the purpose and there is no requirement of inverting the input signal. Also, dual complimentary phases of the output current signal are available from high-output impedance terminals for explicit utilization. As compared to many recently proposed CM rectifiers using complex active devices, e.g. dual-X current conveyor or universal voltage conveyor, our circuit is very compact and requires a total of 21 transistors. SPICE simulation results of the circuit implemented using 0.35 um TSMC CMOS technology are provided which verify the workability of the proposed circuit

Voltage-Mode All-Pass Filters Using Universal Voltage Conveyor and MOSFET-Based Electronic Resistors

The paper presents two novel realizations of voltage-mode first-order all-pass filters. Both circuits use single universal voltage conveyor (UVC), single capacitor, and two grounded resistors. Using the two NMOS transistors-based realizations of the electronic resistor with two symmetrical power supplies, presented all-pass filter circuits can be easily made electronically tunable. Proposed filter structures provide both inverting and non-inverting outputs at the same configuration simultaneously and they have high-input and low-output impedances that are desired for easy cascading in voltage-mode operations. The nonidealities of the proposed circuits are also analyzed and compared. The theoretical results of both circuits are verified by SPICE simulations using TSMC 0.35 μm CMOS process parameters. Based on the evaluation, the behavior of one of the circuits featuring better performance was also experimentally measured using the UVC-N1C 0520 integrated circuit

Factors associated with time delay to carotid stenting in patients with a symptomatic carotid artery stenosis

Treatment of a symptomatic stenosis is known to be most beneficial within 14 days after the presenting event but this can frequently not be achieved in daily practice. The aim of this study was the assessment of factors responsible for this time delay to treatment. A retrospective analysis of a prospective two-center CAS database was carried out to investigate the potential factors that influence a delayed CAS treatment. Of 374 patients with a symptomatic carotid stenosis, 59.1% were treated beyond ≥14 days. A retinal TIA event (OR = 3.59, 95% CI 1.47–8.74, p < 0.01) was found to be a predictor for a delayed treatment, whereas the year of the intervention (OR = 0.32, 95% CI 0.20–0.50, p < 0.01) and a contralateral carotid occlusion (OR = 0.42, 95% CI 0.21–0.86, p = 0.02) were predictive of an early treatment. Similarly, within the subgroup of patients with transient symptoms, the year of the intervention (OR = 0.28, 95% CI 0.14–0.59, p < 0.01) was associated with an early treatment, whereas a retinal TIA as the qualifying event (OR = 6.96, 95% CI 2.37–20.47, p < 0.01) was associated with a delayed treatment. Treatment delay was most pronounced in patients with an amaurosis fugax, whereas a contralateral carotid occlusion led to an early intervention. Although CAS is increasingly performed faster in the last years, there is still scope for an even more accelerated treatment strategy, which might prevent future recurrent strokes prior to treatment

Development and implementation of clinical guidelines : an artificial intelligence perspective

Clinical practice guidelines in paper format are still the preferred form of delivery of medical knowledge and recommendations to healthcare professionals. Their current support and development process have well identified limitations to which the healthcare community has been continuously searching solutions. Artificial intelligence may create the conditions and provide the tools to address many, if not all, of these limitations.. This paper presents a comprehensive and up to date review of computer-interpretable guideline approaches, namely Arden Syntax, GLIF, PROforma, Asbru, GLARE and SAGE. It also provides an assessment of how well these approaches respond to the challenges posed by paper-based guidelines and addresses topics of Artificial intelligence that could provide a solution to the shortcomings of clinical guidelines. Among the topics addressed by this paper are expert systems, case-based reasoning, medical ontologies and reasoning under uncertainty, with a special focus on methodologies for assessing quality of information when managing incomplete information. Finally, an analysis is made of the fundamental requirements of a guideline model and the importance that standard terminologies and models for clinical data have in the semantic and syntactic interoperability between a guideline execution engine and the software tools used in clinical settings. It is also proposed a line of research that includes the development of an ontology for clinical practice guidelines and a decision model for a guideline-based expert system that manages non-compliance with clinical guidelines and uncertainty.This work is funded by national funds through the FCT – Fundação para a Ciência e a Tecnologia (Portuguese Foundation for Science and Technology) within project PEst-OE/EEI/UI0752/2011"

Serum levels of cytokines and C-reactive protein in acute ischemic stroke patients, and their relationship to stroke lateralization, type, and infarct volume

There is increasing evidence that inflammation plays an important role in the progression of acute ischemic stroke (AIS). The primary aims of this study were to examine the serum levels of 13 cytokines, C-reactive protein (CRP), glucose, and hemoglobin in AIS patients, and their relationship to stroke lateralization, type, and infarct volume. Forty-five patients with AIS were evaluated. Blood samples were taken within 72 h, and volumetric analyses performed within 1–7 days after AIS onset. Cytokines were measured in serum from all patients and from 40 control subjects using Luminex Bio-Plex XMap technology. The levels of interleukin (IL)-1ra (p < 0.001), IL-6 (p < 0.001), IL-8 (p < 0.001), IL-9 (p = 0.038), IL-10 (p = 0.001), IL-12 (p = 0.001), IL-18 (p < 0.001), and GRO-α (CXCL1) (p = 0.017) were significantly higher in the AIS patients than in the controls. The IL-8 level was significantly correlated with age in the patient group (r = 0.52, p < 0.001). None of the variables were found to be associated with stroke lateralization. Infarct volume was significantly positively correlated with CRP level (r = 0.47, p = 0.005). Patients with radiologically confirmed infarctions had significantly elevated serum levels of GRO-α (p = 0.023). The cytokine profile of the AIS patients supports not only earlier findings of a proinflammatory response but also early activation of endogenous immunosuppressive mechanisms. Novel findings of this study are elevated serum levels of IL-9 and GRO-α. Elevated GRO-α in AIS patients with radiologically confirmed infarctions suggests that GRO-α is specific for stroke of known etiology. Our results indicate that CRP plays an important role in the progression of cerebral tissue injury